GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2285947 | 1 | rs2285950 | chr7:21584432 | DNAH11 | chr7:21582833-21941455:+ | 0.3 | 5.03 | 7.44E-7 | Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma) |
| BLCA | cis | rs2288073 | 1 | rs2288073 | chr2:24413298 | LOC375190 | chr2:24299728-24397519:+ | 0.22 | 3.88 | 0.000124 | Venous thromboembolism (SNP x SNP interaction) |
| BLCA | cis | rs4776059 | 1 | rs2288271 | chr15:52886466 | ARPP19 | chr15:52839432-52861364:- | 0.22 | 3.97 | 8.59E-5 | Schizophrenia |
| BLCA | cis | rs2289681 | 1 | rs2289681 | chr17:42989088 | CCDC103 | chr17:42977154-42982758:+ | 0.34 | 3.89 | 0.00012 | Cognitive function |
| BLCA | cis | rs7927771 | 1 | rs2290850 | chr11:47807774 | C1QTNF4 | chr11:47611216-47615961:- | -0.29 | -5.41 | 1.11E-7 | Subjective well-being |
| BLCA | cis | rs60843830 | 1 | rs2290911 | chr2:224919 | SH3YL1 | chr2:218138-264810:- | -0.45 | -11.69 | 3.26E-27 | Spherical equivalent (joint main effects and education interaction) |
| BLCA | cis | rs877636 | 1 | rs2292239 | chr12:56482180 | RPS26 | chr12:56435686-56438005:+ | 0.43 | 7.5 | 4.52E-13 | Cognitive function |
| BLCA | cis | rs2294008 | 1 | rs2294008 | chr8:143761931 | LY6D | chr8:143866298-143868008:- | 0.23 | 4.83 | 2.02E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2294008 | chr8:143761931 | PSCA | chr8:143761875-143764142:+ | 0.52 | 15.91 | 4.17E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2294010 | chr8:143762430 | LY6D | chr8:143866298-143868008:- | 0.22 | 4.79 | 2.43E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs2294008 | 1 | rs2294010 | chr8:143762430 | PSCA | chr8:143761875-143764142:+ | 0.51 | 15.95 | 2.78E-44 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| BLCA | cis | rs56322409 | 1 | rs2296691 | chr10:97370989 | ENTPD1 | chr10:97471536-97637022:+ | 0.19 | 4.99 | 9.3E-7 | Blood metabolite levels |
| BLCA | cis | rs798766 | 1 | rs2305188 | chr4:1739592 | FAM53A | chr4:1641609-1685854:- | -0.31 | -4.47 | 1.05E-5 | Urinary bladder cancer;Bladder cancer |
| BLCA | cis | rs17030613 | 1 | rs2306937 | chr1:113246506 | ST7L | chr1:113066142-113162405:- | 0.4 | 5.71 | 2.22E-8 | Diastolic blood pressure;Blood pressure |
| BLCA | cis | rs17030613 | 1 | rs2306940 | chr1:113241052 | ST7L | chr1:113066142-113162405:- | 0.43 | 6.21 | 1.4E-9 | Diastolic blood pressure;Blood pressure |